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Changes in Functional Activity of Rabbit’s Retina During Flicker Photostimulation with Scale-free Dynamics
Vladimir V. Neroev1, Marina V. Zueva2*, Natalia V. Neroeva1, Denis V. Fadeev3, Irina V. Tsapenko2, Tatiana D. Okhotsimskaya1 and Vladislav I. Kotelin2
1Department of Retinal and Optic Nerve Pathology, Helmholtz National Medical Research Center of Eye Diseases, Str.
2Department of Clinical Physiology of Vision, Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russian Federation, Str.
3Scientific Experimental Center, Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russian Federation, Str.
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Abstract:
Neuroplasticity-based stimulation therapy assists in restoring the visual system in neurodegenerative disorders. Scale-free fluctuations peculiar to healthy physiological rhythms disappear as the disease progresses. Fractal visual stimuli positively influence CNS plasticity and increase the efficiency of visual rehabilitation. To determine the effect of a lengthy course of fractal photostimulation (FS) on the electroretinogram (ERG) in healthy rabbits, a device for FS was created. For twelve healthy rabbits, 20-minute FS sessions were conducted once a day from 9 to 11 a.m., five times a week. Before and after 1, 4, and 12 weeks of FS, full-field ERGs, flicker ERGs, and the pattern-ERGs were registered. The observed positive impact of FS consisted of shortening peak latency of the maximal scotopic ERG b-wave and a significant increase in the amplitude of the cone ERG a- and b-waves and low-frequency flicker ERGs (p<0.05). For the first time, we describe the effect of FS on the ERG. The long-term FS does not impair retinal activity and can be safely used in the clinic. The dynamics of the positive influence of FS on retinal activity argue that the duration of the FS course of 1 to 4 weeks is optimal for subsequent studies.
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Keywords: Scale-free dynamics, Fractal photostimulation, Visual rehabilitation, Neuroplasticity, Electroretinogram
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Received:May 08, 2022; Revised:May 20, 2022; Accepted:May 28, 2022; Published:June 30, 2022
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*Corresponding author; e-mail: visionlab@yandex.ru
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Citation:V., V.; V., M.; V., N.; V., D.; V., I.; D., T.; I., V.Changes in Functional Activity of Rabbit’s Retina During Flicker Photostimulation with Scale-free Dynamics. International Journal of Clinical Medicine and Bioengineering 2022, 2, 1-19. https://doi.org/10.35745/ijcmb2022v02.02.0001
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Copyright: ©
2022
The Author(s). Published with license by IIKII, Singapore. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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